Exemplary time-dependent sequences of mean interaction strength and various network characteristics. Sequences derived from multichannel (N = 90), long-term (14.7 days) iEEG recordings from a patient with a focal epilepsy undergoing presurgical evaluation (the patient signed informed consent that the clinical data might be used and published for research purposes, and the study protocol had previously been approved the by ethics committee of the University of Bonn). From top to bottom: mean interaction strength (average over all estimated strength values – calculated using the mean phase coherence R [105] – from all pairs of sampled brain regions), assortativity a, clustering coefficient c, synchronizability s, betweenness centrality of an exemplary brain region near the seizure-generating area, and betweenness centrality of a homologous region in the opposite brain hemisphere. Left column shows full sequences (smoothed with a moving average over 40 windows (13.65 min) to improve legibility, and tics on x-axis denote midnight); right column shows zooms in (1 h segment from day 1) of the unsmoothed sequences. Grey bars mark discontinuities in the sequences due to recording gaps.